The Vim configuration file .vimrc is located in the user's home directory and is used to customize Vim's behavior and appearance. Common configurations include: set number to show line numbers, set relativenumber to show relative line numbers, set tabstop=4 to set tab width, set shiftwidth=4 to set indent width, set expandtab to use spaces instead of tabs, set autoindent for auto indentation, set smartindent for smart indentation, set ignorecase to ignore case in search, set incsearch for incremental search, set hlsearch to highlight search results, syntax on to enable syntax highlighting, set cursorline to highlight current line, set mouse=a to enable mouse support. Plugin managers like Vundle, vim-plug, dein.vim make it easy to install and manage plugins. Through .vimrc configuration, you can create a personalized Vim development environment.